VITAMIN C AND CRANBERRY EXTRACT EFFERVESCENT TABLET FORMULATION, CHARACTERIZATION, AND EVALUATION

Authors

  • Haider Ali Gillani Highnoon Pharmaceuticals Pvt Ltd
  • Dr. Maryam Khalid University of Lahore
  • Sohaid Said University of Poonch Rawalakot AJK
  • Memona Khalid Lahore College and Women University
  • Shaista Umbreen Faculty of Pharmacy, University of Lahore
  • Sonia Tariq Department of Pharmacy, the Islamia University of Bahawalpur,Bahawalpur pakistan

DOI:

https://doi.org/10.56536/ijpihs.v4i1.53

Keywords:

Effervescence, Dosage form, Tablets, Formulation, Cranberry, Effervescent Tablets

Abstract

Background: Effervescent floating tablets are used oral dosage form, to enhance the patient compliance, drug bioavailability and to increase the absorption rate. Cranberry (Vaccinium macrocarpon), widely used as a preventive agent against urinary tract infections, also suggested for Type II diabetes, myalgic encephalomyelitis, scurvy, and as a diuretic pill for being rich in nutrients and anti-oxidant properties. Objectives: The aim of the study is to formulate and evaluate the effervescent tablets of Cranberry and Vitamin C. Methodology: As per defined criteria of US FDA, effervescent tablet as per composition is formulated by citric acid and sodium bicarbonate and intended to dissolve in water before administration. Active substance and excipient compatibility studies were done by UV and FTIR, resulted absence of any interaction. Pre-formulation studies including Bulk density, tapped density, angle of repose, Hausner’s ratio, Carr’s index and water content. Results: Formulations were evaluated for weight variation, thickness, hardness, pH of solution, drug dissolution time, content uniformity as defined specification of U.S.P and BP. Stability and storage condition studies were also monitored with average results of 96% drug assay and dissolution. All the results showed excellent formulation of tablet and flow properties of granules. Conclusion: Further studies required to approach targeted and spontaneous release of active as optimized effervescence maybe helpful in delivery of actives and enhancing patient compliance.

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Published

2023-03-01

How to Cite

Gillani, H. A. ., Khalid , D. M., Said, S. ., Khalid, M., Umbreen, S., & Tariq, S. (2023). VITAMIN C AND CRANBERRY EXTRACT EFFERVESCENT TABLET FORMULATION, CHARACTERIZATION, AND EVALUATION. International Journal of Pharmacy & Integrated Health Sciences, 4(1). https://doi.org/10.56536/ijpihs.v4i1.53