PHARMACOLOGICAL SIGNIFICANCE OF MANGIFERA INDICA IN OVERCOMING PAIN AND IMPROVING LIFE

Abstract

Background: No matter how advanced the world is today, working for this advancement and high standards of life always comes with pain. Since the evolution of humankind, people have been using different products of natural origin for pain management because of their effectiveness and fewer side effects. Objective: The main objective of the current study was to extract the fruit pulp of Mangifera indica and investigate its pharmacological impact. Methodology: Different dosages were evaluated, including 250 and 500 mg/kg of the plant extract. The hot plate method, tail flick, and writhing tests were used to estimate analgesic activity. Carrageenan-induced paw edema was performed to determine the anti-inflammatory response. Results: The obtained data revealed significant activity at 250 mg/kg and highly significant activity at 500 mg/kg via the hot plate method for evaluation. In the tail-flick test, extract at both doses exhibited highly considerable activity. In the writhing test, the maximum inhibition of writhes was observed at a dose of 500 mg/kg, with the number of writhes decreasing from 22 to 11 within 20 minutes, resulting in an inhibition rate of 49.36%. For the carrageenan test, both doses exhibited substantial inhibition outcomes on the mean increase in paw volume for the different periods. Maximum inhibition was observed during the 5 hours of time intervals with 35.74% and 37.85% of doses. Conclusion: The results suggest that Mangifera indica possesses significant medical importance and could be used for therapeutic purposes.